Tris(2-pyridylmethyl)amine (abbreviated TPMA or TPA) is an organic compound with the formula (C<sub>5</sub>H<sub>4</sub>NCH<sub>2</sub>)<sub>3</sub>N. It is a tertiary amine with three picolyl substituents. It is a white solid that is soluble in polar organic solvents. It is a ligand in coordination chemistry.
The ligand is prepared by the alkylation of 2-picolylamine by picolyl chloride:
TPMA is a tripodal ligand, often used to simulate the coordination environment within some proteins. It is also used as a copper ligand in ATRP.