TFMFly, or TFM-FLY, also known as DOTFM-FLY, is a serotonin receptor modulator of the phenethylamine, amphetamine and DOx, and FLY families related to psychedelics like DOTFM and DOB-FLY.
It acts as a potent agonist at the 5HT<sub>2A</sub> serotonin receptor subtype, and is a chiral compound with the more active (R) enantiomer having a K<sub>i</sub> of 0.12 nM at the human 5-HT<sub>2A</sub> receptor. While the fully aromatic benzodifurans such as Bromo-DragonFLY generally have higher binding affinity than saturated compounds like 2C-B-FLY, the saturated compounds have higher efficacy as agonists.
The chemical synthesis of TFMFly has been described.
Analogues of TFMFly include DOTFM, DOB-FLY, and 25TFM-NBOMe, among others.
TFMFly was first reported by a team at Purdue University led by David E. Nichols in 2001.
TFMFly is illegal in Latvia.