25TFM-NBOMe (also known as NBOMe-2C-TFM, 2C-TFM-NBOMe, and Cimbi-138) is a derivative of the phenethylamine hallucinogen 2C-TFM, discovered by Ralf Heim at the Free University of Berlin by 2000. It can be taken to produce psychedelic effects similar to 25I-NBOMe and 25D-NBOMe.
25TFM-NBOMe acts as a potent partial agonist for the serotonin 5-HT<sub>2A</sub> receptor, though its relative potency is disputed, with some studies finding it to be of lower potency than 25I-NBOMe, while others show it to be of similar or higher potency, possibly because of differences in the assay used.
Analogues of 25TFM-NBOMe include 2C-TFM, DOTFM, and TFMFly (DOTFM-FLY), among others.
25TFM-NBOMe was first described in the scientific literature by Ralf Heim and colleagues at the Free University of Berlin by 2000.
25TFM-NBOMe is a controlled substance in Canada under phenethylamine blanket-ban language.