San Gregorio d'Ippona () is a comune (municipality) in the Province of Vibo Valentia in the Italian region Calabria, located about southwest of Catanzaro and about southeast of Vibo Valentia. As of 31 December 2004, it had a population of 2,278 and an area of .
San Gregorio d'Ippona borders the following municipalities: Francica, Jonadi, San Costantino Calabro, and Vibo Valentia.