San Costantino Calabro () is a comune (municipality) in the Province of Vibo Valentia in the Italian region Calabria, located about southwest of Catanzaro and about southwest of Vibo Valentia. As of 31 December 2004, it had a population of 2,320 and an area of .
San Costantino Calabro borders the following municipalities: Francica, Jonadi, Mileto, San Gregorio d'Ippona.