Samuel Clark or Clarke may refer to:
Clark
- Samuel Clark (minister) (1727âÂÂ1769), English minister
- Samuel Clark (New York and Michigan politician) (1800âÂÂ1870), American politician from New York and Michigan
- Samuel Reed Clark (1826âÂÂ?), American politician from Wisconsin
- Samuel M. Clark (1842âÂÂ1900), American politician from Iowa
- Samuel Clark (rugby union) (1857âÂÂ1947), Welsh international rugby player
- Samuel Churchill Clark (1842âÂÂ1862), Confederate military officer
- Samuel Findlay Clark (1909âÂÂ1998), Canadian soldier
- Samuel J. Clark, American demographer
- Samuel Kelly Clark (1924âÂÂ2006), American mechanical engineer known for work in tire mechanics
- S. D. Clark (Samuel Delbert Clark, 1910âÂÂ2003), Canadian sociologist
- Sam Clark (born 1987), Australian actor and singer-songwriter
Clarke
- Samuel Clarke (minister) (1599âÂÂ1683), English clergyman and Puritan biographer
- Samuel Clarke (Archdeacon of Derby) (1582âÂÂ1641), Church of England Laudian cleric and opponent of Puritanism
- Samuel Clarke (annotator) (1626âÂÂ1701), English Nonconformist clergyman known as an assiduous annotator of the Bible
- Samuel Clarke (dean of Clonmacnoise), Anglican priest in Ireland during the 17th century
- Samuel Clarke (1675âÂÂ1729), English philosopher and Anglican clergyman
- Samuel Clarke of St Albans (1684âÂÂ1750), English Nonconformist pastor and theological writer
- Samuel Asahel Clarke (1827âÂÂ1909), Oregon poet, journalist, and historian
- Samuel Clarke (Canadian politician) (1853âÂÂ?), Canadian merchant and politician
- Sam Clarke (motorcyclist) (born 1996), Australian motorcycle racer
- Sir Samuel Clarke, 1st Baronet (died 1719) of the Clarke baronets