Samuel Clarke (July 29, 1853 – July 8, 1928) was a Canadian merchant and political figure. He represented Northumberland West in the Legislative Assembly of Ontario from 1898 to 1926 as a Liberal member.
He was born in Brampton, Canada West, the son of Thomas Clarke. He was mayor of Cobourg from 1887 to 1890. He died on July 8, 1928.