Rice Creek is a stream in Daviess and DeKalb Counties in the U.S. state of Missouri. It is a tributary of Grindstone Creek.
The stream headwaters arise in southwestern Daviess County just west of US Route 69 and approximately one mile north of the community of Mabel at . The stream flows northwest into Dekalb County to its confluence approximately three miles from its source. The confluence is approximately three miles south of Weatherby. The confluence is at .
Rice Creek was named after William Rice, a pioneer citizen.