Mabel is an unincorporated community in southwest Daviess County, in the U.S. state of Missouri.
The community is located adjacent to U.S. Route 69 about east of the Daviess-DeKalb county line and north of the Davies-Caldwell county line. Cameron is six miles to the south-southwest along Route 69.
A post office called Mabel was established in 1883, and remained in operation until 1936. The origin or namesake of the name Mabel is uncertain.