Khairpur District (, ) is a district in the Pakistani province of Sindh in Sukkur Division.
At the 2017 census, it was the fifth most populated district in the province after four districts of Karachi city, with 2.4 million inhabitants. The headquarters of the district is the city of Khairpur. The district is further divided into eight sub-districts: Khairpur Tehsil, Mirwah Tehsil, Kot Diji Tehsil, Kingri Tehsil, Sobho Dero Tehsil, Gambat Tehsil, Faiz Ganj Tehsil and Nara Tehsil.
Khairpur district is located between middle and northern Sindh. It is bounded on the north by Shikarpur District and Sukkur District, on the east by India, on the south by Sanghar District and Nawabshah District, and on the west by Larkana District, Naushahro Feroze District and Indus River. The revised area of the district is 15,910 km<sup>2</sup>.
As of the 2023 census, Khairpur district has 452,250 households and a population of 2,597,535. The district has a sex ratio of 102.69 males to 100 females and a literacy rate of 50.14%: 61.84% for males and 38.10% for females. 891,260 (34.31% of the surveyed population) are under 10 years of age. 844,263 (32.50%) live in urban areas.
The majority religion is Islam, as indicated by 96.78% of the population. Hinduism is practiced by 2.90% of the population, including those from Scheduled Castes.
Sindhi was the predominant language, spoken by 97.73% of the population as their first language.
The District of Khairpur is mapped into three constituencies at the national level. The constituencies include NA-208 Khairpur-I, NA-209 Khairpur-II, and NA-210 Khairpur-III.
Following is the list of the Member National Assemblies(MNAs) representing district in the National Assembly of Pakistan.
The District of Khairpur is represented by the seven constituencies in the Provincial Assembly of Sindh.
It has 8 tehsils, 76 Union councils, 11 towns, 6800 Villages and total population 1,546,587 (Male 810,448 and Female Population 736,139) according to (Census) 1998.
The eight tehsils of the district are: