Otoyol 53 (), abbreviated as O-53, also known as Ceyhan-ðskenderun Otoyolu (), is a toll motorway in Mediterranean Region, Turkey, connecting the Adana-à Âanlñurfa Motorway O-52 with ðskenderun. The motorway is part of international routes as European route E91 and Asian Highway 84.
The O-53 starts from Ceyhan in Adana Province at the junction of O-52, runs southward to ðskenderun South bypassing the city in the east.