N-tert-Butyltryptamine (NtBT) is a psychoactive drug of the tryptamine family related to psychedelics like dimethyltryptamine (DMT).
NtBT was briefly described by Alexander Shulgin in his book TiHKAL (Tryptamines I Have Known and Loved). According to Shulgin, NtBT is active at a dose of 5 to 20mg or of ~20mg orally. He also said that he had heard that NtBT is extremely potent when smoked, but had not received any particulars or confirmed that. Its effects included a lightheaded intoxication described as a totally pleasant buzz, but nothing more profound than that.
Shulgin has said that along with N-sec-butyltryptamine (NsBT), it is one of only two N-mono-substituted tryptamines with known psychoactivity. He also said that N-mono-substituted tryptamines might be GHB-like intoxicants devoid of psychedelic effects. However, N-methyltryptamine (NMT) has been reported to produce psychedelic effects.
Analogues of NtBT include N-methyltryptamine (NMT), N-ethyltryptamine (NET), N-isopropyltryptamine (NiPT), N-benzyltryptamine (NBnT), 4-HO-DsBT, and 4-HO-McPeT, among others.