4-HO-DsBT, also known as 4-hydroxy-N,N-di-sec-butyltryptamine, is a tryptamine derivative which acts as a serotonin receptor agonist.
4-HO-DsBT was first made by Alexander Shulgin and is mentioned in his book TiHKAL (Tryptamines I Have Known and Loved), but was never tested by him.
It has been tested in vitro and unlike the n-butyl and isobutyl isomers which are much weaker, the s-butyl derivative retains reasonable potency, with a similar 5-HT<sub>2A</sub> receptor affinity to MiPT but better selectivity over the 5-HT<sub>1A</sub> and 5-HT<sub>2B</sub> subtypes.
Analogues of 4-HO-DsBT include 4-HO-DBT, 4-HO-DiBT, 4-HO-DtBT, 4-HO-DiPT, 4-HO-McPeT, 4-HO-PiPT, 5-MeO-DBT, dibutyltryptamine (DBT), and N-tert-butyltryptamine (NtBT), among others.
4-HO-DsBT was first described in the scientific literature by David Repke and colleagues by 1981.