The Miss South Carolina USA competition, previously known as Miss South Carolina Universe, is the pageant that selects the representative for the state South Carolina in the Miss USA pageant, and the name of the title held by that winner. The pageant is produced by Paula Miles, the sister of Miss South Carolina USA 1979, Janice McDonald, from 1980 until 2024 under directed by RPM Productions. In 2025 and onwards, the pageant is now produced and directed by Ariana Blaize, Miss Universe Guyana 2024, under A Blaize Productions alongside the rest of former RPM states.
Miriam Stevenson, South Carolina's first Miss USA and the United States' first Miss Universe, was also the first Miss USA winner to have competed at Miss America. She was the first woman to have competed at Miss America, Miss USA, and Miss Universe. South Carolina's second Miss USA was Shawn Weatherly, who also went on to win Miss Universe.
Nine Miss South Carolina USAs have also held the Miss South Carolina Teen USA title and competed at Miss Teen USA. Two have also competed at Miss America.
Miss South Carolina USA titleholders have also competed at two other major international pageants. Gina Tolleson, first runner-up at Miss USA 1990, went on to win the Miss World crown that year, and Miss South Carolina USA 2004, Amanda Pennekamp, has also competed at the Miss Earth 2006 pageant where she made the top 16.
Gallienne Nabila of Greer was crowned Miss South Carolina USA 2025 on August 31, 2025, at The Twichell Auditorium in Spartanburg. She represented South Carolina for the title of Miss USA 2025.
South Carolina holds a record of 40 placements at Miss USA third overall behind Texas and California.