Mexithauma quadripaludium is a species of freshwater snail, an aquatic gastropod mollusc in the family Cochliopidae. It is the only species in the genus Mexithauma.
This species is endemic to Cuatro Ciénegas valley, in the Chihuahuan Desert, Mexico.
Predators of Mexithauma quadripaludium include the cichlid fish Herichthys minckleyi.