Mancha Khiri (, ; , ) is a district (amphoe) in the southern part of Khon Kaen province, northeastern Thailand.
Neighboring districts are (from the north clockwise): Nong Ruea, Ban Fang, Phra Yuen, Ban Haet, Ban Phai, Chonnabot, Khok Pho Chai of Khon Kaen Province; Kaeng Khro and Ban Thaen of Chaiyaphum province.
The district was renamed from Kut Khao to Mancha Khiri in 1939.
The district is divided into eight subdistricts (tambons), which are further subdivided into 116 villages (mubans). Mancha Khiri is a township (thesaban tambon) and covers parts of tambon Kut Khao. There are a further eight tambon administrative organizations (TAO).
<small>Missing numbers belong to subdistricts which now form Khok Pho Chai District.</small>