Khok Pho Chai (, ; , ) is a district (amphoe) of Khon Kaen province, northeastern Thailand.
The minor district (king amphoe) was established on 30 April 1994 by splitting it from Mancha Khiri district.
On 15 May 2007, all 81 minor districts were upgraded to full districts. On 24 August the upgrade became official.
Neighboring districts are (from the north clockwise): Mancha Khiri, Chonnabot, and Waeng Yai of Khon Kaen Province; Khon Sawan and Kaeng Khro of Chaiyaphum province.
The district is divided into four subdistricts (tambons), which are further subdivided into 40 villages (mubans). The township (thesaban tambon) Ban Khok covers parts of tambon Ban Khok. There are a further four tambon administrative organizations (TAO).