Mali made its Paralympic Games début at the 2000 Summer Paralympics in Sydney. The country sent only one athlete (Facourou Sissoko), who competed in powerlifting. He did not win a medal. One of nineteen powerlifters in the men's up to 75 kg category, he lifted 130 kg, placing him last of the seventeen athletes who successfully lifted a weight.
Although Sissoko intended to return to the Games in 2008, he was banned before being able to compete, having been tested positive for steroids.