Mali made its Paralympic Games debut at the 2000 Summer Paralympics in Sydney, sending a single representative (Facourou Sissoko) to compete in powerlifting. In the up-to-75 kg category, he lifted 130 kg, finishing last of the seventeen competitors who successfully lifted a weight. He therefore did not win a medal.
Mali did not compete at the 2004 Paralympic Games because the country sent nine officials instead of the athletes. In 2008, Facourou Sissoko was due to compete as Mali's sole representative, but he was banned after testing positive for boldenone metabolite (a steroid) on the day of the opening ceremony.
Mahamane Sacko represented Mali on the track at the 2012 Summer Paralympics, but did not proceed past the heats.