Lithium tert-butoxide is the metalorganic compound with the formula LiOC(CH<sub>3</sub>)<sub>3</sub>. A white solid, it is used as a strong base in organic synthesis. The compound is often depicted as a salt, and it often behaves as such, but it is not ionized in solution. Both octameric and hexameric forms have been characterized by X-ray crystallography.
Lithium tert-butoxide is commercially available as a solution and as a solid, but it is often generated in situ for laboratory use because samples are so sensitive and older samples are often of poor quality. It can be obtained by treating tert-butanol with butyl lithium.
As a strong base, lithium tert-butoxide is easily protonated.
Lithium tert-butoxide is used to prepare other tert-butoxide compounds such as copper(I) t-butoxide and hexa(tert-butoxy)dimolybdenum(III):