List of investigational sexual dysfunction drugs

This is a list of investigational sexual dysfunction drugs, or drugs that are currently under development for clinical use for the treatment of sexual dysfunction but are not yet approved. Sexual function disorders include anorgasmia, atrophic vaginitis (vaginal atrophy), decreased libido, dyspareunia (painful sexual intercourse), erectile dysfunction, female sexual dysfunction (female sexual arousal disorder (FSAD)/hypoactive sexual desire disorder (HSSD)), male sexual dysfunction, premature ejaculation, vulvodynia (vulva pain), paraphilias, and hypersexuality, among others.

Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. The format of list items is "Name (Synonyms) – Mechanism of Action – Indication [Reference]". The section that the drug is in corresponds to its highest developmental phase, not its phase for all listed indications.

This list was last comprehensively updated in January 2026. It is likely to become outdated with time.

Under development

Preregistration

• Orenetide (BP-101; BP101; Libicore; Desirix) – undefined mechanism of action (synthetic small peptide) – female sexual dysfunction https://adisinsight.springer.com/drugs/800049135 https://synapse.patsnap.com/drug/f9ad9ac0b0124958a1ade85bffcce15d
• Tadalafil oral film (AQST-119; Exordia) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800045028
• Tadalafil oral film (Exordia; INT-007; INT0007; INT0007/2006) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800032840

Phase 3

• Clomipramine/sildenafil (CDFR-0812) – combination of clomipramine (tricyclic antidepressant (TCA), serotonin–norepinephrine reuptake inhibitor (SNRI), other actions) and sildenafil (phosphodiesterase PDE5 inhibitor) – premature ejaculation https://adisinsight.springer.com/drugs/800043564
• Gepirone (Ariza; BMY-13805-1; BMY-13805; Exxua; Gepirone ER; MJ-13805; Org-33062; TGFK07AD; Travivo; Variza) – serotonin 5-HT_1A receptor agonist, other actions – decreased libido https://adisinsight.springer.com/drugs/800000684
• Nitroglycerin gel (Eroxon; glyceryl trinitrate topical gel; MED-2001; MED-2003; MED-2004; MED-2005; MED-3000; MED2002) – guanylate cyclase stimulant, nitric oxide donor, nitric oxide stimulant – erectile dysfunction https://adisinsight.springer.com/drugs/800018028
• Prasterone vaginal (dehydroepiandrosterone; DHEA; Intrarosa; Vaginorm) – androgen (androgen receptor agonist), other actions – decreased libido https://adisinsight.springer.com/drugs/800032054
• Sacubitril/valsartan (AHU-377/valsartan; Enrest; Enresuto; Entresto; Entresto Sprinkle; LCZ-696; LCZ-696A; Neparvis; valsartan/AHU-377; valsartan/sacubitril) – combination of sacubitril (neprilysin inhibitor) and valsartan (angiotensin II receptor type 1 (AT₁) antagonist) – erectile dysfunction https://adisinsight.springer.com/drugs/800028192

Phase 2

• Aildenafil (methisosildenafil) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800057380
• AN-788 (IP-2018; IP2018; NSD788; NSD-788) – serotonin–dopamine reuptake inhibitor (SDRI) – erectile dysfunction https://adisinsight.springer.com/drugs/800028006
• Apomorphine intranasal (AL-101; intranasal apomorphine) – non-selective dopamine receptor agonist, other actions – erectile dysfunction, female sexual dysfunction https://adisinsight.springer.com/drugs/800065343
• Autologous mesenchymal stem cell therapy (autologous bone marrow-derived mesenchymal stem cell therapy; Cellgram; Cellgram-ED; Cellgram-LC; Cerecellgram-spine; Hearticellgram-AMI; Immunocellgram; Impocellgram; Livercellgram; Lungcellgram; MSC-1; MSC-2) – cell replacement – erectile dysfunction https://adisinsight.springer.com/drugs/800023673
• Botulinum toxin A (AboBoNT-A; AbobotulinumtoxinA; Alluzience; Azzalure; BoNT-A; BTX-A-HAC; BTX-A-HAC NG; Clostridium botulinum toxin type A haemagglutinin complex; Dysport; Dysport NG; Dysport RU; Dysport Solution; Dysport Next Generation; Reloxin) – acetylcholine release inhibitor and neuromuscular blocking agent – vulvodynia https://adisinsight.springer.com/drugs/800010369
• Bupropion/trazodone (Lorexys; Orexa; S1P-104; S1P-205; SIP-104; trazodone/bupropion) – combination of bupropion (norepinephrine–dopamine reuptake inhibitor (NDRI), other actions) and trazodone (serotonin antagonist and reuptake inhibitor (SARI), various actions) – erectile dysfunction, female sexual dysfunction, male sexual dysfunction https://adisinsight.springer.com/drugs/800035655
• Buspirone/testosterone (Lybridos; testosterone/buspirone) – combination of buspirone (serotonin 5-HT_1A receptor agonist, other actions) and testosterone (androgen) – female sexual dysfunction https://adisinsight.springer.com/drugs/800040046
• BZ-371A (PnPP-19) – nitric oxide stimulant – erectile dysfunction, female sexual dysfunction https://adisinsight.springer.com/drugs/800052534
• Cligosiban (IX-01; PF-3274167) – oxytocin receptor antagonist – premature ejaculation https://adisinsight.springer.com/drugs/800038534
• Estetrol (Donesta; E4) – estrogen (estrogen receptor agonist) – atrophic vaginitis, female sexual dysfunction https://adisinsight.springer.com/drugs/800044874
• Estriol vaginal ring (VR-102; VR102; long-acting estriol vaginal ring) – estrogen (estrogen receptor agonist) – atrophic vaginitis https://adisinsight.springer.com/drugs/800072355
• Fadanafil (XZP-5849) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800046145
• FKW-00GA (FKW00GA; TGW-00AA; TGW00AA; TGWOOAA; TGW-OOAA) – serotonin 5-HT_1A receptor agonist, serotonin 5-HT_2A receptor antagonist – sexual function disorders https://adisinsight.springer.com/drugs/800029565
• LIB-01 (DIC-2024; DIC2024; Libiguin) – indirect melanocortin MC₄ receptor potentiator – erectile dysfunction, premature ejaculation https://adisinsight.springer.com/drugs/800047257
• Onabotulinum toxin A (BoNTA; Botox; botulinum toxin A injectable; GSK-1358820; GSK1358820; OnabotA X; OnabotulinumtoxinA X; Vistabel; Vistabex) – acetylcholine release inhibitor and neuromuscular blocking agent – premature ejaculation https://adisinsight.springer.com/drugs/800008810
• OPK-88004 (LY-2452473; TT701) – selective androgen receptor modulator (SARM) – erectile dysfunction https://adisinsight.springer.com/drugs/800033580
• Pudafensine (IP2015; IP-2015) – serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) – erectile dysfunction, vulvodynia, female sexual dysfunction https://adisinsight.springer.com/drugs/800066919
• Sildenafil/testosterone (Lybrido; testosterone/sildenafil) – combination of sildenafil (phosphidiesterase PDE5 inhibitor) and testosterone (androgen) – female sexual dysfunction https://adisinsight.springer.com/drugs/800040043
• Sildenafil topical – phosphodiesterase PDE5 inhibitor – female sexual dysfunction https://adisinsight.springer.com/drugs/800051315
• Testosterone intranasal (low-dose) (MPP-14; Noseafix; TBS-2; Tefina) – androgen (androgen receptor agonist) – anorgasmia, decreased libido https://adisinsight.springer.com/drugs/800029680
• TGFK-09SD (TGFK09SD) – serotonin 5-HT_1A receptor agonist – female sexual dysfunction https://adisinsight.springer.com/drugs/800032503

Phase 1/2

• Mirabegron (Betanis; Betmiga; Betmiga PR; Myrbetriq; Myrbetriq Granules; YM-178) – β₃-adrenergic receptor agonist – erectile dysfunction https://adisinsight.springer.com/drugs/800017376

Phase 1

• KH-001 (KH001) – atypical selective serotonin reuptake inhibitor (SSRI), phosphodiesterase (PDE) inhibitor (purified Sceletium tortuosum (kanna) alkaloid; possibly mesembrine) – premature ejaculation https://adisinsight.springer.com/drugs/800069314
• VV-913 (VV913) – undefined mechanism of action – premature ejaculation https://adisinsight.springer.com/drugs/800086117

Clinical phase unknown

• Sildenafil orally-dissolving film (NAL8238; NAL-8238; sildenafil ODF) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800044988
• Tadalafil orally-dissolving film (NAL8233; NAL-8233; tadalafil ODF) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800044990

Preclinical

• CF-602 – adenosine A₃ receptor modulator – erectile dysfunction https://adisinsight.springer.com/drugs/800055852
• S1B-307 – "central nervous system modulator" – anorgasmia, female sexual dysfunction https://adisinsight.springer.com/drugs/800081805
• S1B-408 – undefined mechanism of action – anorgasmia https://adisinsight.springer.com/drugs/800079153
• S1B-3006 (S1B0-3006; S1B3006) – "central nervous system modulator" – sexual function disorders https://adisinsight.springer.com/drugs/800081819

Phase unknown

• Pirenzepine topical (topical pirenzepine; WST-057; WST-1; WST01; WST1/analgesic; WST57) – muscarinic acetylcholine M₁ receptor antagonist – sexual function disorders https://adisinsight.springer.com/drugs/800047282

Not under development

No development reported

• AB-101 (RJ-101) – undefined mechanism of action – female sexual dysfunction https://adisinsight.springer.com/drugs/800052680
• Apomorphine intranasal – non-selective dopamine receptor agonist, other actions – erectile dysfunction, female sexual dysfunction https://adisinsight.springer.com/drugs/800013441
• Armodafinil ((R)-modafinil; <small>D</small>-modafinil; NH-02D; NH02D) – atypical dopamine reuptake inhibitor (DRI) – premature ejaculation https://adisinsight.springer.com/drugs/800032832 https://synapse.patsnap.com/drug/d583294f007c4483a874455aa643b354
• Deuterated testosterone (d3-testosterone) – androgen (androgen receptor agonist) – female sexual dysfunction https://adisinsight.springer.com/drugs/800065467
• Epelsiban (GSK557296; GSK-557296) – oxytocin receptor antagonist – premature ejaculation https://adisinsight.springer.com/drugs/800033691
• Estradiol/testosterone topical gel (LibiGel-E/T; testosterone/estradiol topical gel) – combination of estradiol (estrogen) and testosterone (androgen) – female sexual dysfunction https://adisinsight.springer.com/drugs/800016817
• Fibroblast growth factor 1 (FGF-1; FGF1; Acidic FGF; aFGF; Cardio Vascu-Grow; CVBT-141P ; CVBT-141S; CVBT-141A; CVBT-141B; CVBT-141C; CVBT-141D; CVBT-141E; CVBT-141ED; CVBT-141F; CVBT-141G; CVBT-141H; FGF-1(141); VT-141D; VT-141ED; VT-141P; VT-141S) – fibroblast growth factor receptor (FGFR) agonist – erectile dysfunction https://adisinsight.springer.com/drugs/800020529
• FKK-01PD (FKK-01PD; TGHW-01AP; TGHW01AP) – non-selective dopamine receptor agonist, other actions (apomorphine prodrug) – erectile dysfunction https://adisinsight.springer.com/drugs/800029674
• GSK-958108 (GSK958108) – serotonin 5-HT_1A receptor antagonist – premature ejaculation https://adisinsight.springer.com/drugs/800033198
• HCP-1302 (HCP1302) – undefined mechanism of action – erectile dysfunction https://adisinsight.springer.com/drugs/800043406
• Lidocaine topical gel – sodium channel blocker, local anesthetic – dyspareunia https://adisinsight.springer.com/drugs/800054063
• PTL-2015 – undefined mechanism of action – erectile dysfunction https://adisinsight.springer.com/drugs/800041761
• Research programme: nerve-targeted gene therapy - Periphagen (NC-3; NE-2; NE2-Endomorphin; NG-2; NG2-GAD; NN1-Neurotrophin) – various actions – erectile dysfunction https://adisinsight.springer.com/drugs/800026952
• Research programme: sexual dysfunction therapy - Palatin Technologies (PL-6983) – melanocortin receptor modulators – erectile dysfunction, female sexual dysfunction https://adisinsight.springer.com/drugs/800028349
• Sildenafil (KW-25084) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800045463
• Sildenafil orally soluble film (CURE-5003; CUREfilm Blue) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800054403
• Sildenafil oral spray (Duromist; NVD-401; SUD-003; SUD-004; SUDA-004; Sudamist) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800032185
• Tadalafil dry powder inhalation (Tadalafil Technosphere) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800056557
• Tadalafil orodispersible film tablet (Caliberi) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800049653
• Tadalafil topical (Extrinsa) – phosphodiesterase PDE5 inhibitor – female sexual dysfunction https://adisinsight.springer.com/drugs/800050318
• Tadalafil/tamsulosin – combination of tadalafil (phosphodiesterase PDE5 inhibitor) and tamsulosin (α₁-adrenergic receptor antagonist) – erectile dysfunction https://adisinsight.springer.com/drugs/800047508
• Tunodafil (ecocarbamate; gluconocin; yonkenafil) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800041605
• Vilazodone (EMD-68843; SB-659746A; Viibryd) – serotonin reuptake inhibitor (SRI), serotonin 5-HT_1A receptor agonist – sexual function disorders https://adisinsight.springer.com/drugs/800008976
• Zotarolimus (ABT-578; Endeavor; Endeavor Resolute; MDT-4107 DES; Resolute DES; Resolute Integrity; Resolute Onyx; ZoMaxx) – FK-binding protein 12 (FKBP12) ligand and mechanistic target of rapamycin (mTOR) inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800018378

Preregistration submission withdrawal

• Lasofoxifene (AZU-101; CP-336156; CP-336156-CB; Fablyn; HLX-78; Oporia) – selective estrogen receptor modulator (SERM) – atrophic vaginitis https://adisinsight.springer.com/drugs/800007522

Suspended

• Alprostadil topical (Alprox-TD; Befar; Cold Chain Vitaros; Femprox; RayVa; Room Temperature Vitaros; Virirec; Vitaros; Vytaros; WC-3036) – prostaglandin E1 (PGE1) agonist – female sexual dysfunction https://adisinsight.springer.com/drugs/800010547

Discontinued

• Acolbifene/prasterone (dehydroepiandrosterone/acolbifene; DHEA/acolbifene; prasterone/acolbifene; Femivia) – combination of acolbifene (selective estrogen receptor modulator (SERM)) and prasterone (dehydroepiandrosterone; DHEA) (androgen, other actions) – decreased libido https://adisinsight.springer.com/drugs/800043933
• Alprostadil SEPA (prostaglandin E1 SEPA; alprostadil/soft enhancement of percutaneous absorption; Topiglan) – prostaglandin E1 (PGE1) agonist – erectile dysfunction https://adisinsight.springer.com/drugs/800010551
• Alprostadil/lidocaine (NM02216; NM100061) – combination of alprostadil (prostaglandin E1 (PGE1) agonist) and lidocaine (sodium channel blocker, local anesthetic) – premature ejaculation https://adisinsight.springer.com/drugs/800019217
• Amesergide (LY-237733; LY237733; LY-237,733) – serotonin 5-HT_2A, 5-HT_2B, and 5-HT_2C receptor antagonist, other actions – erectile dysfunction, premature ejaculation https://adisinsight.springer.com/drugs/800001117
• Apomorphine inhalation (VR-004; VR-040; VR-400) – non-selective dopamine receptor agonist, other actions – erectile dysfunction, female sexual dysfunction https://adisinsight.springer.com/drugs/800018754
• Apomorphine intranasal – non-selective dopamine receptor agonist, other actions – erectile dysfunction https://adisinsight.springer.com/drugs/800017357
• Avanafil (Razatus; Spedra; Stendra; TA-1790; Zepeed) – phosphodiesterase PDE5 inhibitor – female sexual dysfunction, premature ejaculation https://adisinsight.springer.com/drugs/800015525
• BAY-604552 (BAY98-7081; sGC activator) – guanylate cyclase stimulant – erectile dysfunction https://adisinsight.springer.com/drugs/800028283
• Bremelanotide (Rekynda; Vyleesi; PT-141) – melanocortin MC₄ receptor agonist – erectile dysfunction https://adisinsight.springer.com/drugs/800014146
• CP-866087 (CP-866,087) – μ-opioid receptor antagonist – female sexual dysfunction https://adisinsight.springer.com/drugs/800025577
• DA-8031 (DA8031) – selective serotonin reuptake inhibitor (SSRI) – premature ejaculation https://adisinsight.springer.com/drugs/800032011
• Dapoxetine (IMD dapoxetine; YHD-1044) – selective serotonin reuptake inhibitor (SSRI) – premature ejaculation https://adisinsight.springer.com/drugs/800034841
• Delequamine (RS-15385; RS-15385197) – α₂-adrenergic receptor antagonist – erectile dysfunction https://adisinsight.springer.com/drugs/800004435
• Estradiol/testosterone transdermal (testosterone/estradiol transdermal) – combination of estradiol (estrogen) and testosterone (androgen) – female sexual dysfunction https://adisinsight.springer.com/drugs/800011418
• GM-1485 (GPI-1485; NIL-A) – immunophilin modulator – erectile dysfunction https://adisinsight.springer.com/drugs/800010875
• Heparin/lidocaine/sodium bicarbonate (alkalised lidocaine and heparin formulation; Hep-Lido-A compounded formulation; U-101; URG-101) – combination of heparin (Factor Xa inhibitor, thrombin inhibitor), lidocaine (sodium channel blocker, local anesthetic), and sodium bicarbonate (absorption enhancer) – dyspareunia https://adisinsight.springer.com/drugs/800023371
• hMaxi-K gene therapy (pVAX/hSlo; URO-902) – gene transference – erectile dysfunction https://adisinsight.springer.com/drugs/800024362
• INO-1001 (INO1001; Pardex) – poly(ADP-ribose) polymerase inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800017281
• LGD-2941 (LGD2941; LGD122941; LGD-122941) – selective androgen receptor modulator (SARM) – female sexual dysfunction, male sexual dysfunction https://adisinsight.springer.com/drugs/800013541
• Melanotan II (MT-II; PT-14) – melanocortin receptor agonist – erectile dysfunction, male sexual dysfunction https://adisinsight.springer.com/drugs/800010143
• Milnacipran (Dalcipran; F-2207; Impulsor; Ixel; Joncia; Midacipran; Midalcipran; Savella; TN-912; Toledomin) – serotonin–norepinephrine reuptake inhibitor (SNRI) – vulvodynia https://adisinsight.springer.com/drugs/800000712
• Nitroglycerin topical (Anogesic; Cellegesic; Rectiv; Rectogesic) – nitric oxide donor – dyspareunia, vulvodynia https://adisinsight.springer.com/drugs/800012295
• NMI-870 – α₂-adrenergic receptor antagonist, nitric oxide donor – erectile dysfunction, female sexual dysfunction https://adisinsight.springer.com/drugs/800014166
• Oxytocin (oxytocin gel; oxytocin topical; Vagitocin) – oxytocin receptor agonist – atrophic vaginitis https://adisinsight.springer.com/drugs/800033176
• Pagoclone (IP-456; Panex; RP-62955) – GABA_A receptor positive allosteric modulator and nonbenzodiazepine/cyclopyrrolone – premature ejaculation https://adisinsight.springer.com/drugs/800002118
• PF-446687 (PF-00446687; PF-446,687) – melanocortin MC₄ receptor agonist – sexual function disorders https://adisinsight.springer.com/drugs/800025591
• PF-592379 (PF-000592379; PF-592,379) – dopamine D₃ receptor agonist – erectile dysfunction https://adisinsight.springer.com/drugs/800025529
• Research programme: therapeutics - Re-Pharm (RP-0217; RP0217) – protein phosphatase 2A (PP2A) inhibitor – sexual function disorders https://adisinsight.springer.com/drugs/800046951 https://synapse.patsnap.com/drug/bef6a521d0894396abd68a934e3323f7
• RO-0282425 (RO0282425) – melanocortin MC₄ receptor agonist – erectile dysfunction https://adisinsight.springer.com/drugs/800024669
• RTN-001 (KD-027; SLX-2101; SLx-2101) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800022583
• SAR-407899 (SAR407899; SAR407899A) – Rho-associated kinase inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800026023
• Sertraline (Aremis; Besitran; CP-51974; CP-51974-01; Gladem; J Zoloft; Lustral; Serad; Serlain; Tatig; Zoloft) – selective serotonin reuptake inhibitor (SSRI) – premature ejaculation https://adisinsight.springer.com/drugs/800006147
• Sildenafil (Revatio; Revatio IV; UK-92480; Viagra) – phosphodiesterase PDE5 inhibitor – female sexual dysfunction https://adisinsight.springer.com/drugs/800006675
• Tadalafil (Adcirca; Cialis; GF-196960; IC-351; LY-450190; Zalutia) – phosphodiesterase PDE5 inhibitor – female sexual dysfunction https://adisinsight.springer.com/drugs/800009738
• Tadalafil sublingual (APC-8000) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800052570
• Tadalafil/tamsulosin (CKD-397; tamsulosin/tadalafil) – combination of tadalafil (phosphodiesterase PDE5 inhibitor) and tamsulosin (α₁-adrenergic receptor antagonist) – erectile dysfunction https://adisinsight.springer.com/drugs/800041550
• Tadalafil/tamsulosin (YBH-1603) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800044412
• Testosterone topical (ESP-210) – androgen (androgen receptor agonist) – female sexual dysfunction https://adisinsight.springer.com/drugs/800011411
• Testosterone transdermal (FemTestosterone TDS) – androgen (androgen receptor agonist) – female sexual dysfunction https://adisinsight.springer.com/drugs/800014546
• Testosterone transdermal (Luramist; testosterone MDTS; testosterone transdermal spray) – androgen (androgen receptor agonist) – female sexual dysfunction https://adisinsight.springer.com/drugs/800020263
• TEMPE (Topical Eutectic Mixture for Premature Ejaculation) – undefined mechanism of action – premature ejaculation https://adisinsight.springer.com/drugs/800020209
• UK-357903 (UK-357,903) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800013332
• UK-390957 (UK-390,957) – serotonin reuptake inhibitor (SRI) – premature ejaculation https://adisinsight.springer.com/drugs/800017934
• UK-447841 (UK-447,841) – neprilysin inhibitor – female sexual dysfunction https://adisinsight.springer.com/drugs/800039893
• VML-670 (VML670; CEB-1555) – serotonin 5-HT_1A receptor agonist – female sexual dysfunction, male sexual dysfunction https://adisinsight.springer.com/drugs/800010723

Clinically used drugs

Approved drugs

Phosphodiesterase PDE5 inhibitors

• Avanafil (Razatus; Spedra; Stendra; TA-1790; Zepeed) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800015525
• Lodenafil (CRIS-031; Helleva) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://synapse.patsnap.com/drug/7f69f3d2387047378d13aba8ce1d0c9a
• Mirodenafil (Aibishi; Bravonto; Mvix; SK-3530) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800022984
• Sildenafil (Revatio; Revatio IV; UK-92480; Viagra) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800006675
• Sildenafil chewable tablets (Nurigra) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800039749
• Sildenafil orally soluble film (sildenafil ODF; SPO-1101; Vultis) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800043176
• Sildenafil orally soluble film (orodispersible sildenafil; Please; sildenafil oral dissolving film; sildenafil orally-disintegrating film; sildenafil OSF) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800040518
• Sildenafil oral spray (ASP-001; ASP-002; Bandol; Hezkue) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800060722
• Sildenafil oro-dispersible tablets (Erecta; FACSID-50) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800043277
• Simmerafil (Onvita; Onweida; semenafil; TPN-171; TPN-171-H) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800059661
• Tadalafil (Adcirca; Cialis; GF-196960; IC-351; LY-450190; Zalutia) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800009738
• Tadalafil oral disintegrating film (SPO-1102; Vulteum; tadalafil ODF) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800043179
• Tadalafil oral film (OGOOD) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800050908
• Udenafil (DA-8159; Jurvigo; ME-3113; MZ101; Udzire; WC-3043; WC-3055; Zydena) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800015258
• Vardenafil (BAY-389456; Levitra; Nuviva; Staxyn; vardenafil ODT; vardenafil orodispersible tablet; Vivanza) – phosphodiesterase PDE5 inhibitor – erectile dysfunction https://adisinsight.springer.com/drugs/800013544

Prostaglandin E1 (PGE1) agonists

• Alprostadil (Caverject; Prostaglandin E1) – prostaglandin E1 (PGE1) agonist – erectile dysfunction https://adisinsight.springer.com/drugs/800010550
• Alprostadil alfadex (alprostadil alfadex complex; alprostadil-alpha-cyclodextrin; Edex; Prostaglandin E1-α-cyclodextrin complex; Prostandin; Prostavasin; Rigidur; Sugiran; Vasaprostan; Vasoprost; Viridal) – prostaglandin E1 (PGE1) agonist – erectile dysfunction https://adisinsight.springer.com/drugs/800011750
• Alprostadil topical (Alprox-TD; Befar; Cold Chain Vitaros; Femprox; RayVa; Room Temperature Vitaros; Virirec; Vitaros; Vytaros; WC-3036) – prostaglandin E1 (PGE1) agonist – erectile dysfunction https://adisinsight.springer.com/drugs/800010547

Estrogens (estrogen receptor agonists)

• Conjugated estrogens (conjugated equine estrogens; CEEs; Premarin) – estrogen (estrogen receptor agonist) – atrophic vaginitis, dyspareunia https://adisinsight.springer.com/drugs/800011836
• Conjugated estrogens oral (Enjuvia; synthetic conjugated estrogens) – estrogen (estrogen receptor agonists) – atrophic vaginitis https://adisinsight.springer.com/drugs/800017322
• Conjugated estrogens/bazedoxifene (Aprela; bazedoxifene acetate/conjugated estrogens; bazedoxifene/conjugated estrogens; bazedoxifene/Premarin; BZA/CE; CE/BZA; conjugated estrogens/bazedoxifene acetate; Duavee; Duavive; Premarin/bazedoxifene; SERM + Premarin) – combination of conjugated estrogens (estrogen) and bazedoxifene (selective estrogen receptor modulator (SERM)) – atrophic vaginitis https://adisinsight.springer.com/drugs/800017580
• Estradiol (Estrofem; Innofem; oral estradiol; Vagifem; vaginal estradiol) – estrogen (estrogen receptor agonist) – atrophic vaginitis https://adisinsight.springer.com/drugs/800013221
• Estradiol transdermal micro patch (Estradot; Minivelle; Vivelle-Dot) – estrogen (estrogen receptor agonist) – atrophic vaginitis https://adisinsight.springer.com/drugs/800017170
• Estradiol vaginal (E2; 17β-estradiol; Estradiol VagiCap; Imvexxy; Joyesta; TX-12-004-HR; TX-004HR; VagiCap; Yuvvexy) – estrogen (estrogen receptor agonist) – atrophic vaginitis https://adisinsight.springer.com/drugs/800036377
• Estradiol acetate (Estrace; estradiol acetate intravaginal ring; estradiol acetate IVR; Femring; Menoring) – estrogen (estrogen receptor agonist) – atrophic vaginitis https://adisinsight.springer.com/drugs/800013176
• Estriol succinate vaginal gel (6α-hydroxyestradiol; Blissel; Gelistrol) – estrogen (estrogen receptor agonist) – atrophic vaginitis https://adisinsight.springer.com/drugs/800047660
• Estriol/lactobacillus (estriol-Lactobcillus acidophilus mixt.; estriol/lyophilised lactobacilli; Gynoflor; ultra-low dose estrogen/lactobacillus) – combination of estriol (estrogen) and lactobacillus (probiotic) – atrophic vaginitis https://adisinsight.springer.com/drugs/800050964
• Ospemifene (FC-1271a; Ophena; Osphena; Senshio) – selective estrogen receptor modulator (SERM) – atrophic vaginitis, dyspareunia https://adisinsight.springer.com/drugs/800011057

Other sex-hormonal agents

• Prasterone vaginal (dehydroepiandrosterone; DHEA; Intrarosa; Vaginorm) – androgen (androgen receptor agonist), other actions – atrophic vaginitis, dyspareunia https://adisinsight.springer.com/drugs/800032054
• Testosterone propionate (TP; Synandrol; Synerone) – androgen (androgen receptor agonist) – decreased libido https://adisinsight.springer.com/drugs/800013172
• Tibolone (Livial) – androgen, estrogen, and progestogen – atrophic vaginitis, dyspareunia, low sexual desire https://adisinsight.springer.com/drugs/800008188
• Triptorelin (Arvekap; AY-25650; BIM-21003; BN-52014; CL-118532; Debio-8200; Debio-8206; debio8200; Decapeptyl; Decapeptyl SR; Decapeptyl LP; Diphereline; Gonapeptyl; Moapar; Pamorelin; Pamorelin LA; Salvacyl; Trelstar; Trelstar Depot; Triptodur; Triptoreline; Tryptorelin; WY-42422) – gonadotropin-releasing hormone (GnRH) receptor agonist – paraphilias https://adisinsight.springer.com/drugs/800004444

Other drugs

• Apomorphine (Ixense; Spontane; TAK-251; Uprima) – non-selective dopamine receptor agonist, other actions – erectile dysfunction https://adisinsight.springer.com/drugs/800010470
• Bremelanotide (Rekynda; Vyleesi; PT-141) – melanocortin MC₄ receptor agonist – female sexual dysfunction https://adisinsight.springer.com/drugs/800014146
• Dapoxetine (LY-210448; LY210448; LY-210,448; Priligy) – selective serotonin reuptake inhibitor (SSRI) – premature ejaculation https://adisinsight.springer.com/drugs/800001262
• Flibanserin (Addyi; BIMT-17; BIMT-17-BS; Girosa) – serotonin 5-HT_1A receptor agonist, serotonin 5-HT_2A receptor antagonist, other actions – female sexual dysfunction https://adisinsight.springer.com/drugs/800002174
• Lidocaine/prilocaine (Fortacin; Prilocaine Lidocaine Plethora; prilocaine/lidocaine; PSD-502; Senstend; Tempe) – combination of lidocaine (sodium channel blocker, local anesthetic) and prilocaine (sodium channel blocker, local anesthetic) – premature ejaculation https://adisinsight.springer.com/drugs/800022970
• Moxisylyte (thymoxamine) – α₁-adrenergic receptor antagonist – erectile dysfunction
• Papaverine (Pavabid) – phosphodiesterase PDE10A inhibitor, other actions – erectile dysfunction
• Phentolamine (Vasomax) – α₁- and α₂-adrenergic receptor antagonist – erectile dysfunction

Combination drugs

• Acecarbromal/quebracho/vitamin E (Afrodor) – various actions – erectile dysfunction
• Aviptadil/phentolamine (Invicorp; phentolamine/aviptadil; PSD-510; Vasopotin) – combination of aviptadil (vasoactive intestinal peptide (VIP) receptor agonist) and phentolamine (α-adrenergic receptor antagonist) – erectile dysfunction https://adisinsight.springer.com/drugs/800008235
• Papaverine/phentolamine – combination of papaverine (phosphodiesterase PDE10A inhibitor, other actions) and phentolamine (α-adrenergic recpetor antagonist) – erectile dysfunction
• Tadalafil/tamsulosin (Gugutams cap.; HCP-1303) – combination of tadalafil (phosphodiesterase PDE5 inhibitor) and tamsulosin (α₁-adrenergic receptor antagonist) – erectile dysfunction https://adisinsight.springer.com/drugs/800041356

Market withdrawal

• Conjugated estrogens oral (Cenestin; synthetic conjugated estrogens) – estrogen (estrogen receptor agonist) – atrophic vaginitis https://adisinsight.springer.com/drugs/800011835
• Testosterone transdermal (Intrinsa; Intrinsa CHF; Livensa; Testosterone transdermal TheraDerm MTX; WC3048; WC3049) – androgen (androgen receptor agonist) – female sexual dysfunction https://adisinsight.springer.com/drugs/800011421

Off-label drugs

• α₂-Adrenergic receptor antagonists (e.g., yohimbine, rauwolscine (found in yohimbe)) – erectile dysfunction, low sexual desire
• Androgens/anabolic steroids (androgen receptor agonists) (e.g., testosterone, testosterone esters, methyltestosterone) – low sexual desire
• Antiandrogens (e.g., GnRH modulators, high-dose estrogen therapy, high-dose progestogen therapy) – various mechanisms of action – paraphilias, hypersexuality, sexual deviance
• Antipsychotics (e.g., haloperidol) – dopamine receptor antagonists, other actions – paraphilias, hypersexuality, sexual deviance
• Bupropion (Wellbutrin, Zyban) – norepinephrine–dopamine reuptake inhibitor (NDRI), other actions – low sexual desire
• Buspirone (Buspar) – serotonin 5-HT_1A receptor agonist, other actions – low sexual desire
• Clomipramine (Anafranil) – tricyclic antidepressant (TCA), serotonin–norepinephrine reuptake inhibitor (SNRI), other actions – premature ejaculation
• Cyproheptadine (Periactin) – non-selective serotonin receptor antagonist, other actions – anorgasmia, low sexual desire/decreased libido
• Estrogens (e.g., estradiol, estradiol esters, ethinylestradiol) – estrogens (estrogen receptor agonists) – atrophic vaginitis, dyspareunia, vulvodynia, low sexual desire
• Horny goat weed (Epimedii herba) – unknown mechanism of action – low sexual desire
• Selective serotonin reuptake inhibitors (SSRIs) (e.g., sertraline, fluoxetine, paroxetine, citalopram, escitalopram) – premature ejaculation, paraphilias, hypersexuality, sexual deviance
• Selegiline (<small>L</small>-deprenyl; Eldepryl, Zelapar, Emsam) – monoamine oxidase B (MAO-B) inhibitor, other actions – low sexual desire
• Tramadol (Tramal) – μ-opioid receptor agonist, serotonin–norepinephrine reuptake inhibitor (SNRI), other actions – premature ejaculation
• Trazodone (Desyrel, Oleptro) – serotonin antagonist and reuptake inhibitor (SARI), various actions – erectile dysfunction, low sexual desire

Recreational drugs

• Alcohol (ethanol/ethyl alcohol) – GABA_A receptor positive allosteric modulator
• Alkyl nitrites (poppers) (e.g., amyl nitrite) – nitric oxide donors, vasodilators, muscle relaxants, inhalants
• Cannabinoids (e.g., THC, cannabis, synthetic cannabinoids) – cannabinoid CB₁ receptor agonists
• Dissociative hallucinogens (e.g., ketamine, methoxetamine, phencyclidine (PCP)) – ionotropic glutamate NMDA receptor antagonists
• Entactogens (empathogens) (e.g., MDMA (ecstasy), mephedrone, 6-APB, borax combo) – serotonin–norepinephrine–dopamine releasing agents (SNDRAs), other actions
• γ-Hydroxybutyric acid (GHB; oxybate) and prodrugs (e.g., GBL, 1,4-BD) – GABA_B and GHB receptor agonists
• Phosphodiesterase PDE5 inhibitors (e.g., sildenafil, tadalafil, vardenafil, avanafil)
• Psychostimulants (stimulants) (e.g., amphetamine, methamphetamine, cocaine, mephedrone (4-MMC), metaphedrone (3-MMC), MDPV) – norepinephrine–dopamine releasing agents (NDRAs) and/or norepinephrine–dopamine reuptake inhibitors (NDRIs)
• Serotonergic psychedelics (e.g., 2C-B, 5-MeO-DiPT, 5-MeO-MiPT) – serotonin 5-HT_2A receptor agonists

See also

• Lists of investigational drugs

References

External links

• AdisInsight - Springer