List of investigational fibromyalgia drugs

This is a list of investigational fibromyalgia drugs, or drugs that are currently under development for clinical use in the treatment of fibromyalgia but are not yet approved.

Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. The format of list items is "Name (Synonyms) – Mechanism of Action [Reference]".

This list was last comprehensively updated in September 2025. It is likely to become outdated with time.

Under development

Preregistration

• Esreboxetine ((S,S)-Reboxetine; AXS-14; PNU-165442G) – norepinephrine reuptake inhibitor (NRI) https://adisinsight.springer.com/drugs/800040151

Phase 3

• Pregabalin controlled release (GRO-12; Lyrica CR; Pregabalin CR; Pregabalin ER) – gabapentinoid (α₂δ subunit-containing voltage-gated calcium channel ligand) https://adisinsight.springer.com/drugs/800034344

Phase 2

• Celecoxib/famciclovir (famciclovir/celecoxib; IMC-1) – combination of celecoxib (COX inhibitor/NSAID) and famciclovir (antiviral) https://adisinsight.springer.com/drugs/800041673
• Mirtazapine (Avanza; Azamianserin; ME-2040; Mepirzapin; Norset; ORG-3770; Promyrtil; Reflex; Remergil; Remergon; Remeron; Rexer; Zispin) – tetracyclic antidepressant (TeCA) (non-selective monoamine receptor modulator and other actions) https://adisinsight.springer.com/drugs/800000714
• ONO-1110 – endocannabinoid synthesis regulator and indirect cannabinoid receptor modulator https://adisinsight.springer.com/drugs/800072581 https://synapse.patsnap.com/drug/4a1d21a5511d57cc2a2c1e7a98310f74 https://pryzm.ozmosi.com/product/29482
• Opiranserin (Unafra; VVZ-000149; VVZ-149) – glycine transporter 2 (GlyT2) blocker, purine P2X₃ receptor antagonist, and serotonin 5-HT_2A receptor antagonist https://adisinsight.springer.com/drugs/800038462
• Psilocybin (PFN™; TRP-8802; TRP-8803; TRP-8804; TRYP-0082) – non-selective serotonin receptor agonist and psychedelic hallucinogen https://adisinsight.springer.com/drugs/800060245
• Rozanolixizumab (Rystiggo; UCB-7665) – monoclonal antibody against neonatal Fc receptor (FcRn) https://adisinsight.springer.com/drugs/800041009

Research

• Celecoxib/valacyclovir (IMC-2; valacyclovir/celecoxib) – combination of celecoxib (COX inhibitor/NSAID) and valacyclovir (antiviral) https://adisinsight.springer.com/drugs/800065434

Not under development

Suspended

• ETX-155 – GABA_A receptor positive allosteric modulator and neurosteroid https://adisinsight.springer.com/drugs/800063923

No development reported

• ASP-0819 (ASP0819) – calcium-activated potassium channel opener https://adisinsight.springer.com/drugs/800046933
• CT-38 – corticotropin-releasing factor CRF₂ receptor agonist https://adisinsight.springer.com/drugs/800052600
• Elcubragistat (ABX-1431; Lu-AG06466) – monoacylglycerol lipase (MAGL) inhibitor https://adisinsight.springer.com/drugs/800042817
• Galcanezumab (Emgality; LY-2951742) – monoclonal antibody against calcitonin gene-related peptide (CGRP) https://adisinsight.springer.com/drugs/800034098
• Lacosamide (ADD-234037; Erlosamide; Harkoseride; SPM-927; SPM-929; Vimpat; Vimpato) – various actions https://adisinsight.springer.com/drugs/800011364
• Pregabalin controlled release (Pregabalin XR; Regabatin XR) – gabapentinoid (α₂δ subunit-containing voltage-gated calcium channel ligand) https://adisinsight.springer.com/drugs/800037085
• Research programme: cannabis extract therapeutics - Cannabis Science – cannabinoid receptor modulators https://adisinsight.springer.com/drugs/800031716
• Research programme: pregabalin gastric-retentive - ProTect (NPRx-1000; PRTT-200) – gabapentinoid (α₂δ subunit-containing voltage-gated calcium channel ligand) https://adisinsight.springer.com/drugs/800032046
• Ropinirole (Adartrel; Repreve; Requip) – dopamine D₂, D₃, and D₄ receptor agonist https://adisinsight.springer.com/drugs/800001120
• SER-282 – undefined mechanism of action https://adisinsight.springer.com/drugs/800004046
• Somatropin (Nutrophin; Nutropin; SMP-140) – growth hormone (GH) replacement https://adisinsight.springer.com/drugs/800006386
• Sunobinop (IMB-115; IT-1315; RSC-117957; S-117957; V-117957) – nociceptin receptor agonist https://adisinsight.springer.com/drugs/800035863

Discontinued

• AD-337 – serotonin–norepinephrine reuptake inhibitor (SNRI) https://adisinsight.springer.com/drugs/800022514
• Ampreloxetine (TD-9855) – serotonin–norepinephrine reuptake inhibitor (SNRI) https://adisinsight.springer.com/drugs/800026474
• ASP-8062 – GABA_B receptor positive allosteric modulator https://adisinsight.springer.com/drugs/800046940
• Desvenlafaxine (DVS-233; MD-120; O-desmethylvenlafaxine; Pristiq; WY-45233) – serotonin–norepinephrine reuptake inhibitor (SNRI) https://adisinsight.springer.com/drugs/800000550
• Droxidopa (3,4-dihydroxyphenylserine; 3,4-threo-DOPS; DOPS; Northera; threo-DOPS) – norepinephrine precursor and indirect non-selective adrenergic receptor agonist https://adisinsight.springer.com/drugs/800025748
• Eslicarbazepine acetate (Aptiom; BIA 2-093; ESL; Exalief; SEP-0002093; SEP-2093; Stedesa; Zebinix) – sodium channel blocker https://adisinsight.springer.com/drugs/800012911
• Faxeladol (GRT-9906; GRT9906) – μ-opioid receptor (MOR) agonist and serotonin–norepinephrine reuptake inhibitor (SNRI) (tramadol analogue) https://adisinsight.springer.com/drugs/800032836
• Fremanezumab (Ajovy; LBR-101; PF-04427429; PF-4427429; RN-307; TEV-48125) – monoclonal antibody against calcitonin gene-related peptide (CGRP) https://adisinsight.springer.com/drugs/800024333
• Galantamine (galanthamine; GP-37267; Nivalin; R-113675; Razadyne; Reminyl) – acetylcholinesterase inhibitor https://adisinsight.springer.com/drugs/800004115
• Ibutamoren (L-163191; LUM-201; MK-0677; MK-677; Oratrope) – ghrelin receptor agonist and growth hormone secretagogue https://adisinsight.springer.com/drugs/800007434
• Interferon α2a (IFN-α lozenges; MOR-22; Veldona) – interferon α stimulant and immunomodulator https://adisinsight.springer.com/drugs/800008731
• Nabilone (Cesamet) – cannabinoid CB₁ and CB₂ receptor agonist https://adisinsight.springer.com/drugs/800025856
• PF-738502 – undefined mechanism of action https://adisinsight.springer.com/drugs/800025505
• Pramipexole (BI-Sifrol; Daquiran; Mirapex; Mirapexin; Pexola; Sifrol; SND-919; SND-919Y) – dopamine D₂, D₃, and D₄ receptor agonist https://adisinsight.springer.com/drugs/800001191
• Pregabalin sustained release (EASOPSRTFP) – gabapentinoid (α₂δ subunit-containing voltage-gated calcium channel ligand) https://adisinsight.springer.com/drugs/800047522
• Radafaxine (GW-353162; (2S,3S)-hydroxybupropion) – norepinephrine–dopamine reuptake inhibitor (NDRI) https://adisinsight.springer.com/drugs/800017221
• Research programme: fibromyalgia therapies - Cypress Bioscience/Georgetown University – undefined mechanism of action https://adisinsight.springer.com/drugs/800015984
• Rotigotine transdermal (Leganto; N-0437; N-0923; Neupro; Nubrenza; SPM-962) – non-selective dopamine receptor agonist and other actions https://adisinsight.springer.com/drugs/800012067
• Sodium oxybate (γ-hydroxybutyrate; GHB; JZP-6; KEY-10; Xyrem) – GABA_B receptor agonist and GHB receptor agonist https://adisinsight.springer.com/drugs/800008211
• Terguride (Dironyl; Mysalfon; SH-406; Teluron; Transdihydrolisuride; VUFB-6638; ZK-31224) – non-selective dopamine receptor agonist, non-selective serotonin receptor modulator, and other actions https://adisinsight.springer.com/drugs/800000563
• Tizanidine (AN-021A; AN-021; DS-103282-CH; DS-103282; Sirdalud; Ternelin; Zanaflex) – α₂-adrenergic receptor agonist https://adisinsight.springer.com/drugs/800007024
• Ubidecarenone (Bio-Quinone Q10; Coenzyme Q10; CoQ10; Neuquinon; Q-Gel; UbiQGel; Ubiquinone; Vitaline) – antioxidant and immunomodulator https://adisinsight.springer.com/drugs/800004348
• ZYN-001 (δ⁹-THC <small>D</small>-glyceric acid ester; THC prodrug transdermal patch) – cannabinoid CB₁ and CB₂ receptor agonist https://adisinsight.springer.com/drugs/800041360

Clinically used drugs

Approved

• Cyclobenzaprine (KRL-102; TNX-102; Tonmya) – tricyclic antidepressant (TCA) (non-selective monoamine reuptake inhibitor and monoamine receptor modulator) https://adisinsight.springer.com/drugs/800017946
• Duloxetine (Ariclaim; Cymbalta; LY-227942; LY-248686; Xeristar; Yentreve) – serotonin–norepinephrine reuptake inhibitor (SNRI) https://adisinsight.springer.com/drugs/800001785
• Milnacipran (Dalcipran; F-2207; Impulsor; Ixel; Joncia; Midacipran; Midalcipran; Savella; TN-912; Toledomin) – serotonin–norepinephrine reuptake inhibitor (SNRI) https://adisinsight.springer.com/drugs/800000712
• Pregabalin (CI-1008; isobutylgaba; Lyrica; PD-144723) – gabapentinoid (α₂δ subunit-containing voltage-gated calcium channel ligand) https://adisinsight.springer.com/drugs/800005758

Off-label drugs

• Anticonvulsants (e.g., lacosamide)
• Cannabinoids (cannabinoid receptor modulators) (e.g., cannabis, tetrahydrocannabinol (THC), cannabidiol (CBD), nabilone)
• Capsaicin – transient receptor potential vanilloid receptor 1 (TRPV1) agonist
• Carisoprodol (Soma) – muscle relaxant
• Gabapentinoids (α₂δ subunit-containing voltage-gated calcium channel ligands) (e.g., gabapentin, gabapentin enacarbil, mirogabalin)
• Hypnotics (e.g., zolpidem)
• Melatonin – melatonin receptor agonist
• Monoamine oxidase inhibitors (MAOIs) (e.g., moclobemide, pirlindole)
• Non-steroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen, aspirin)
• Paracetamol (acetaminophen) – analgesic
• Selective serotonin reuptake inhibitors (SSRIs) (e.g., citalopram, fluoxetine, paroxetine)
• Sodium oxybate (γ-hydroxybutyrate; GHB; Xyrem) – GABA_B receptor agonist and GHB receptor agonist
• Serotonin–norepinephrine reuptake inhibitors (SNRIs) (e.g., desvenlafaxine, levomilnacipran, venlafaxine)
• Tetracyclic antidepressants (TeCAs) (e.g., mirtazapine)
• Tizanidine (Zanaflex) – α₂-adrenergic receptor agonist
• Tramadol (Tramal) – weak μ-opioid receptor (MOR) agonist and serotonin–norepinephrine reuptake inhibitor (SNRI)
• Tricyclic antidepressants (TCAs) (e.g., amitriptyline)
• Tropisetron – serotonin 5-HT₃ receptor antagonist

See also

• Lists of investigational drugs
• List of investigational ME/CFS drugs
• List of investigational long COVID drugs
• List of investigational analgesics

References

External links

• AdisInsight - Springer