L-759,656 is an analgesic drug that is a cannabinoid agonist. It is a highly selective agonist for the CB<sub>2</sub> receptor, with selectivity of 414x for CB<sub>2</sub> over CB<sub>1</sub>, although it is still not as selective as newer agents such as HU-308.
It produces some similar effects to other cannabinoid agonists such as analgesia, but with little or no sedative or psychoactive effects due to its weak CB<sub>1</sub> activity, and a relatively strong antiinflammatory effect due to its strong activity at CB<sub>2</sub>.