Khaneh Khamis-e Sofla (, also Romanized as KhÃÂneh Khamës-e Soflá; also known as KhÃÂnkhamës-e Soflá) is a village in Siyakh Darengun Rural District, in the Central District of Shiraz County, Fars province, Iran. At the 2006 census, its population was 713, in 144 families.