The Kamenets-Podolsky uezd was a county (uezd) of the Podolian Governorate of the Russian Empire. The uezd bordered the Proskurov uezd to the north, the Ushitsa uezd to the east, the Khotin uezd to the south, and Austria to the west. Its administrative centre of the county was Kamenets-Podolsky (modern-day Kamianets-Podilskyi). The county covered most of the area of Kamianets-Podilskyi Raion.
The subcounties (volosts) of the Kamenets-Podolsky uezd in 1912 were as follows:
At the time of the Russian Empire Census on , the Kamenets-Podolsky uezd had a population of 266,350, including 132,750 men and 133,600 women. The majority of the population indicated Little Russian to be their mother tongue, with significant Jewish and Great Russian speaking minorities.