Jerzu (Sardinian: Jersu), is a comune (municipality) in the Province of Ogliastra in the Italian region Sardinia, located about northeast of Cagliari and about southwest of Tortolì. As of 31 December 2004, it had a population of 3,287 and an area of . Jerzu is known for the production of a particular type of wine, called Cannonau di Jerzu.
Jerzu borders the following municipalities: Arzana, Cardedu, Gairo, Lanusei, Osini, Tertenia, Ulassai, Villaputzu.