JWH-307 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB<sub>1</sub> and CB<sub>2</sub> receptors. It is somewhat selective for the CB<sub>2</sub> subtype, with a K<sub>i</sub> of 7.7 nM at CB<sub>1</sub> vs 3.3 nM at CB<sub>2</sub>. It was discovered by, and named after, John W. Huffman. JWH-307 was detected as an ingredient in synthetic cannabis smoking blends in 2012, initially in Germany.
In the United States, CB<sub>1</sub> receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-307 are Schedule I Controlled Substances.