JWH-147 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB<sub>1</sub> and CB<sub>2</sub> receptors. It is somewhat selective for the CB<sub>2</sub> subtype, with a K<sub>i</sub> of 11.0 nM at CB<sub>1</sub> vs 7.1 nM at CB<sub>2</sub>. It was discovered and named after the renowned professor of organic chemistry John W. Huffman.
In the United States, CB<sub>1</sub> receptor agonists of the 3-(1-naphthoyl)pyrrole class such as JWH-147 are Schedule I Controlled Substances.
JWH-147 was banned in Sweden on 1 October 2010 as harmful to health, after being identified as an ingredient in "herbal" synthetic cannabis products.