JWH-185 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the carbonyl-reduced derivative of related compound JWH-081. The binding affinity of JWH-185 for the CB<sub>1</sub> receptor is reported as K<sub>i</sub> = 17 ñ 3 nM.
In the United States, all CB<sub>1</sub> receptor agonists of the 3-(1-naphthylmethane)indole class such as JWH-185 are Schedule I Controlled Substances.