JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB<sub>1</sub> and CB<sub>2</sub> receptors. With a K<sub>i</sub> of 1.2nM it is fairly selective for the CB<sub>1</sub> subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB<sub>2</sub>(12.4nM). It was discovered by and named after John W. Huffman.
JWH-081 may be neurotoxic to animals when administered in high doses.
In the United States, JWH-081 is a Schedule I Controlled Substance.
As of October 2015, JWH-081 is a controlled substance in China.