JWH-116 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the indole 2-ethyl derivative of related compound JWH-018. The binding affinity of JWH-116 for the CB<sub>1</sub> receptor is reported as K<sub>i</sub> = 52 ñ 5 nM.
In the United States, all CB<sub>1</sub> receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-116 are Schedule I Controlled Substances.