The Shire of Hepburn is a local government area in Victoria, Australia. Located in the central part of the state, it covers an area of . The recorded a population of 16,604 in the shire.
Notable settlements include Clunes, Creswick, Daylesford, Hepburn Springs, Trentham, Allendale, Denver, Glenlyon, Kingston, Leonards Hill, Lyonville, Newlyn and Smeaton.
The shire is governed and administered by the Hepburn Shire Council; its seat of local government and administrative centre is located at the council headquarters in Daylesford. It also has a service centre located in Creswick. The shire is named after an early squatter named John Hepburn, who established the Smeaton Hill pastoral run, which was located a few kilometres north of present-day Creswick.
The Shire of Hepburn was formed in 1995 from the amalgamation of the Shire of Creswick, Shire of Daylesford and Glenlyon, the Trentham district of the Shire of Kyneton, and the Clunes district of the Shire of Talbot and Clunes.
The council is composed of seven councillors, the councillors are:
The council meets in the council chambers at the council headquarters in the Daylesford Municipal Offices, which is also the location of the council's administrative activities. It also provides customer services at both its administrative centre in Daylesford, and its service centre in Creswick.
At the , the shire had a population of 16,604, up from 15,330 at the census.
^ - Territory divided with another LGA<br> * - Not noted in 2016 Census<br> # - Not noted in 2021 Census
The traditional owners of the Shire of Hepburn are the Dja Dja Wurrung.