HLA-B75 (B75) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.
B75 is one of many s of the , B15. B75 (B*1502) is associated with a severe drug-induced skin condition in ethnic East Asians.
HLA-B*1502 is associated with carbamazepine and phenytoinâÂÂinduced StevensâÂÂJohnson syndrome in Chinese and Thai people. One study showed a 100% association between B*1502 and the drug-induced skin disorder in a Chinese population. In Europe the B*1502 positive patients are only found in this syndrome of persons of East Asian descent, however B58 confers susceptibility to both groups but to a lesser degree and is sensitive to allopurinol.