HLA-B58 (B58) is an HLA-B serotype. B58 is a from the B17 , the sister serotype B57. The serotype identifies the more common HLA-B*58 gene products. (For terminology help see: HLA-serotype tutorial) B*5801 is associated with allopurinol induced inflammatory necrotic skin disease.
HLA-B*5801 is involved in allopurinol sensitive drug induced StevensâÂÂJohnson syndrome. Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, StevensâÂÂJohnson syndrome, and toxic epidermal necrolysis (SJS/TEN). The association with allopurinol sensitivity in SJS/TEN was extremely strong in Asia, and somewhat less associated in Europeans.