Guatemala is scheduled to compete in the 2023 Parapan American Games in Santiago, Chile from 17 November to 26 November 2023. This was Guatemala's fifth appearance at the Parapan American Games, having first competed in the 2007 edition.
Paralympic athlete Andrés de León and goalball player Velveth Higueros were the country's flagbearers during the opening ceremony.
The following Guatemalan competitors won medals at the games. In the discipline sections below, the medalists' names are bolded.
The following is the list of number of competitors (per gender) participating at the games per sport/discipline.