Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)

In enzymology, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) () is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are D-glyceraldehyde-3-phosphate, phosphate (P_i), and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 1,3-bisphosphoglyceric acid, reduced NADH, and a proton. This enzyme participates in glycolysis and gluconeogenesis.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating). Other names in common use include triosephosphate dehydrogenase, dehydrogenase, glyceraldehyde phosphate, phosphoglyceraldehyde dehydrogenase, 3-phosphoglyceraldehyde dehydrogenase, NAD+-dependent glyceraldehyde phosphate dehydrogenase, glyceraldehyde phosphate dehydrogenase (NAD+), glyceraldehyde-3-phosphate dehydrogenase (NAD+), NADH-glyceraldehyde phosphate dehydrogenase, and glyceraldehyde-3-P-dehydrogenase.

See also

• Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) which catalyses the same reaction using nicotinamide adenine dinucleotide phosphate as its cofactor

References

Further reading