Glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)

In enzymology, glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) () is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are D-glyceraldehyde 3-phosphate, phosphate (P_i), and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are 1,3-bisphosphoglyceric acid, reduced NADPH, and a proton.

Function

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in the Calvin cycle which is an autotrophic carbon fixation pathway.

Nomenclature

The systematic name of this enzyme class is D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase (phosphorylating). Other names in common use include:

• dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
• GAPDH
• glyceraldehyde phosphate dehydrogenase (nicotinamide adenine dinucleotide phosphate) (phosphorylating)
• glyceraldehyde-3-phosphate dehydrogenase (NADP) (phosphorylating)
• NADP-dependent glyceraldehyde phosphate dehydrogenase
• NADP-glyceraldehyde phosphate dehydrogenase
• NADP-glyceraldehyde-3-phosphate dehydrogenase
• NADP-triose phosphate dehydrogenase
• triosephosphate dehydrogenase (NADP)

See also

• Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) which catalyses the same reaction using nicotinamide adenine dinucleotide as its cofactor

References