Estradiol diacetate (EDA), or estradiol 3,17ò-diacetate, is an estrogen and an estrogen esterâÂÂspecifically, the C3 and C17ò diacetate ester of estradiolâÂÂwhich was never marketed. It is related to the estradiol monoesters estradiol acetate (estradiol 3-acetate; Femtrace) and estradiol 17ò-acetate.