Elisa Desco (born 30 May 1982) is an Italian female sky runner and mountain runner, world champion at the 2014 Skyrunning World Championships held in Chamonix, and European champion at the 2008 European Mountain Running Championships held in Zell am Harmersbach.
She was also world champion at individual senior level she won 7 medals (1 gold individual and 6 with the national team) at the 2008 World Mountain Running Championships but was disqualified for doping.
Her partner is the Italian mountain running champion Marco De Gasperi. They live in Bormio with their two daughters, Lidia (2011) and Cecilia (2017).