Sardar Dost Muhammad Khosa (; born 22 October 1973) is a Pakistani politician affiliated with Pakistan People's Party. He was elected as 15th Chief Minister of Punjab on 11 April 2008, serving until 8 June 2008. He served for only 58 days.
He joined the Pakistan People's Party (PPP) on 22 December 2018.
Khosa is the son of former Punjab Governor and senior political leader of Pakistan Sardar Zulfiqar Ali Khosa. He was born in Lahore on 22 October 1973.
Khosa received his primary education from Aitchison College Lahore, and graduated from University of the Punjab.While at Aitchison College, Khosa was the member of the college football,riding and athletics team.
Khosa was first elected as MPA when his father vacated a provincial seat after taking oath as Punjab Governor in August 1999. He had also served as UC Nazim of Churratta, D.G. Khan and later as Naib District Nazim D.G. Khan until the general election in 2008. Having been elected as an MPA, he got elected as the youngest Chief Minsiter of the Punjab and relinquished the charge for Mian Muhammad Shahbaz Sharif. Khosa later on also served as Minister for Public Health Engineering, Housing & Urban Development; Environment; and Local Government & Community Development Departments during 2008-13
In the 2018 general elections, he contested election (PP-289) as an independent candidate but lost.
In 2024 Pakistani elections he contest from NA-185 Dera Ghazi Khan-II and PP-289 Dera Ghazi Khan and lost both, to independent candidates.
After disqualification of Zartaj Gul of Pakistan Tehreek-e-Insaf (PTI), he contest by election from NA-185 Dera Ghazi Khan-II, and lost to Mehmood Qadir Khan of PML(N).
Khosa belongs to a Baloch tribe. He is the youngest of three sons of former Punjab Governor Sardar Zulfiqar Ali Khosa.