NA-185 Dera Ghazi Khan-II () is a constituency for the National Assembly of Pakistan. It mainly comprises the city of Dera Ghazi Khan which was in the old NA-172 before the 2018 delimitations.
General elections were held on 10 October 2002. Farooq Ahmad Khan Laghari of National Alliance won by 56,343 votes.
General elections were held on 18 February 2008. Farooq Ahmad Khan Laghari of PML-Q won by 45,370 votes.
General elections were held on 11 May 2013. Hafiz Abdul Kareem of PML-N won by 49,230 votes and became the member of National Assembly.
General elections were held on 25 July 2018.
Elections were held on 8 February 2024. Zartaj Gul won the election with 94,927 votes.
A by-election will be held on 23 November 2025 due to the disqualification of Zartaj Gul, the previous member from this seat.