Coyame del Sotol is one of the 67 municipalities of Chihuahua, in northern Mexico. The municipal seat is Coyame. The municipality covers an area of .
As of the 2010 census, the municipality had a total population of 1,681.
The municipality had 232 localities, none of which had a population over 1,000.
"Coyame" is the Apache toponym of a nearby arroyo. "Sotol" is the local name for Dasylirion wheeleri, a flowering desert plant, and for sotol, a distilled mezcal-like spirit made from it.
The municipality has 46 localities. These are the largest: