Guadalupe is one of the 67 municipalities of Chihuahua, in northern Mexico. The capital lies at Guadalupe. The municipality covers an area of 6,200.5 km<sup>2</sup>.
As of 2010, the municipality had a total population of 6,458,
Other than the town of Guadalupe, the municipality had 195 localities, none of which had a population over 1,000.
The municipality has 80 localities. The largest are:
A narcofosa (mass grave attributed to organized crime) containing the remains of 13 people was discovered in Bravos in June 2018.