NA-46 Islamabad-I () is a constituency for the National Assembly of Pakistan.
The constituency consists of a mix of urban and rural areas of Islamabad Capital Territory from Sector G-10 to Tarnol and also includes Sector I-10. During 2018 delimitation, NA-49 (Islamabad-II) constituency was divided between this constituency and NA-53 (Islamabad-II). On the granular basis, the following areas of Islamabad are included in this constituency:
General elections were held on 10 October 2002. Mian Muhammad Aslam of Muttahida Majlis-e-Amal won by 40,365 votes.
The result of general election 2008 in this constituency is given below. Anjum Aqeel Khan succeeded in the election 2010 and became the member of National Assembly.
Javed Hashmi succeeded in the 2013 general election and became the member of National Assembly.
The seat fell vacant after Javed Hashmi choose to retain his Multan constituency. A re-election was held on 22 August 2013 in which Asad Umar secured a win with 48,073 votes his closest rival was PML-N Chaudhary Muhammad Ashraf Gujjar who came second at 41,186 votes
General elections were held on 25 July 2018. Asad Umar managed to retain his seat he won in the 2013 by-election.
General elections were held on 8 February 2024. Anjum Aqeel Khan won the election with 82,536 votes.