NA-45 Dera Ismail Khan-II () is a constituency for the National Assembly of Pakistan. The constituency was created in 2018 by bifurcating NA-25 (Dera Ismail Khan-cum-Tank) where Tank district shared its representation with a portion of Dera Ismail Khan District. In 2018, Tank District got its own constituency while the Dera Ismail Khan areas of the old constituency are now included in NA-39 (Dera Ismail Khan-II). In 2022 the Constituency number is changed into NA-45 (Dera Ismail Khan-II).
General elections were held on 25 July 2018.
General elections were held on 8 February 2024. Fatehullah Khan Miankhel won the election with 56,944 votes.