CUMYL-4CN-BINACA (also known as CUMYL-CYBINACA or SGT-78) is an indazole-3-carboxamide based synthetic cannabinoid that has been sold online as a designer drug. It is a potent agonist for cannabinoid receptors CB<sub>1</sub> and CB<sub>2</sub>, with in vitro EC<sub>50</sub> values of 0.58 nM and 6.12 nM, respectively. In mice, CUMYL-4CN-BINACA produces hypothermic and pro-convulsant effects via the CB<sub>1</sub> receptor, and anecdotal reports suggest it has an active dose of around 0.1 mg in humans.
CUMYL-4CN-BINACA is metabolized to produce cyanide, raising concerns about liver toxicity. There is one reported case of hyperthermia, rhabdomyolysis, and kidney failure associated with its use.