5-MeO-DsBT, also known as 5-methoxy-N,N-di-sec-butyltryptamine, is a chemical compound and possible psychedelic drug of the tryptamine and 5-methoxytryptamine families related to 5-MeO-DMT. It was briefly mentioned by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved). He described it as being an unknown compound. Relatedly, its route, dose, and duration were not described. 5-MeO-DsBT was first described in the literature by Shulgin in TiHKAL in 1997. It is a skeletal isomer of 5-MeO-DBT. Subsequently, close analogues of 5-MeO-DsBT like 5-MeO-MsBT and 5-MeO-NsBT emerged as novel designer drugs in the early 2020s. 5-MeO-DsBT is not a controlled substance in Canada as of 2025.