4-Thiotrisescaline (4-T-TRIS), also known as 4-thiotrescaline or as 4-ethylthio-3,5-diethoxyphenethylamine, is a chemical compound of the phenethylamine and scaline families related to mescaline. It is the analogue of trisescaline (TRIS; trescaline) in which the ethoxy group at the 4 position has been replaced with an ethylthio group. The drug is one of two possible thiotrisescaline (T-TRIS; thiotrescaline) positional isomers, the other being 3-thiotrisescaline (3-T-TRIS; 3-thiotrescaline).
In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 4-T-TRIS's dose as greater than 200mg orally and its duration as unknown. The effects of 4-T-TRIS have been reported to include possibly some physical effects, slight tingling or numbing of hands and fingers, gas, and no mental effects at a dose of 120mg orally in one report. However, in another report in which a higher dose of 200mg orally was used, there were, aside from a brief passing awareness, no physical or mental effects whatsoever. Shulgin concluded that the compound is inactive.
The chemical synthesis of 4-T-TRIS has been described.
4-T-TRIS was first described in the scientific literature by Shulgin and Peyton Jacob III in 1984. Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.