3-Thiotrisescaline (3-T-TRIS), also known as 3-thiotrescaline or as 3-ethylthio-4,5-diethoxyphenethylamine, is a chemical compound of the phenethylamine and scaline families related to mescaline. It is the analogue of trisescaline (TRIS; trescaline) in which the ethoxy group at the 3 position has been replaced with an ethylthio group. The drug is one of two possible thiotrisescaline (T-TRIS; thiotrescaline) positional isomers, the other being 4-thiotrisescaline (4-T-TRIS; 4-thiotrescaline).
In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 3-T-TRIS's dose as greater than 160mg orally and its duration as unknown. 3-T-TRIS produced no effects at tested doses of up to 160mg orally, with the exception of possible neurological irritability 9 or 10hours after administration. Shulgin concluded that the compound is inactive.
The chemical synthesis of 3-T-TRIS has been described.
3-T-TRIS was first described in the scientific literature by Shulgin and Peyton Jacob III in 1984. Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.