A substituted 3-benzazepine, or simply 3-benzazepine, is a derivative of 3-benzazepine. They are cyclized phenethylamines and are closely related to the tetrahydroisoquinolines. In addition, they are analogous to the cyclized tryptamine ibogalogs and their ò-carboline relatives.
3-Benzazepines are known to act as monoamine receptor modulators, including as dopamine D<sub>1</sub>-like receptor agonists, dopamine D<sub>1</sub> receptor antagonists, and serotonin 5-HT<sub>2A</sub>, 5-HT<sub>2B</sub>, and 5-HT<sub>2C</sub> receptor agonists, among other activities. 3-Benzazepines acting as serotonin 5-HT<sub>2</sub> receptor agonists generally show varying degrees of preferential activity at the serotonin 5-HT<sub>2C</sub> receptor over the serotonin 5-HT<sub>2A</sub> receptor, with occasional exceptions. One 3-benzazepine, the non-selective serotonin 5-HT<sub>2</sub> receptor agonist and previously marketed anorectic lorcaserin (Belviq), is known to produce psychedelic effects at supratherapeutic doses.